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Many growth factors such as transforming growth factor (TGF)-, 2 platelet-derived growth factor (PDGF), 3 epidermal growth factor (EGF), 4 and fibroblast growth factor (FGF), 5 as well as interleukin (IL)-1 6 and tumor necrosis factor (TNF), 7 have been evaluated in a wide spectrum of in vivo and in vitro experiments to observe their effects on different elements included in the healing process
The combined effect on IGF-1 may be greater than either peptide alone, necessitating periodic lab work to ensure levels remain in a safe, therapeutic range
17 Table 3
Occlusion of the superior mesenteric artery in rats reversed by collateral pathways activation: Gastric pentadecapeptide BPC 157 therapy counteracts multiple organ dysfunction syndrome, intracranial, portal and caval hypertension, and aortal hypotension
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